Clinical trial evaluating the effects of a reduced iso-alpha acids (RIAA), rosemary extract, and oleanolic acid supplement on parameters of platelet function and blood coagulation

Several botanical and therapeutic agents have been reported to have adverse effects on platelet function; therefore, evaluating the effect of a novel anti-inflammatory on platelet function and blood coagulation is an essential step in clinical safety assessment. In this report, we present the findings of a clinical trial assessing the effect of Meta050 (1 week at 2 tablets bid) on parameters of blood coagulation and platelet function. The results indicate Meta050 has no direct effect on blood coagulation. Moreover, Meta050 does not appear to influence platele t function. This observation is consistent with in vitro data that indicates Meta050 does not inhibit the COX enzymes.